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Electrospun fibers with altered drug release profiles resulting from changes in polymer crystallinity
RPI ID: 2016-017-401 and 2016-017-601
Innovation Summary:
This invention presents a drug delivery platform based on electrospun polymeric fibers that enable controlled, localized, and sustained release of therapeutic agents. The system uses biodegradable polymers to encapsulate drugs within nanofibers, allowing for precise tuning of release kinetics...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Anthony D'Amato, Andrew Fiumara, Paul Troiano, Jesus Cardenas, Ryan Gilbert, Nicholas Schaub
Keywords(s): Biomedical Engineering, Delivery, Drug Delivery, Materials, Polymers
Category(s): Biotechnology and the Life Sciences
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Implantable Multilayer 3D Scaffold Consisting of Highly Aligned Electrospun Fibers for Neuronal Regeneration Applications
RPI ID: 2016-014-401, 2016-014-601Innovation Summary:This invention introduces a 3D scaffold composed of curved, highly aligned electrospun fibers designed to promote neural regeneration. The scaffold mimics natural guidance structures found in peripheral nerve grafts, using polymer fibers arranged in S-shaped or C-shaped conduits. It may incorporate...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Ryan Gilbert, Jared Cregg, Bing Wang, Michael Mullins, Martin Oudega, Andres Hurtado
Keywords(s): biocompatible, Biomedical Engineering, Electrospinning, Electrospun Fibers, Implant, Material science, Nerve Regeneration, PLLA, Polymers, scaffold, Spinal Cord Injury
Category(s): Biotechnology and the Life Sciences
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Rapid Filtration Methods for Dual-energy X-ray CT
RPI ID: 2016-056-401, 2016-056-601, 2016-056-602, 2016-056-603Innovation Summary:This portfolio features a suite of advanced filtration technologies developed to enhance the performance of dual-energy X-ray computed tomography (DECT) systems. These innovations address key limitations in spectral separation, motion artifact reduction, and computational...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Wenxiang Cong, Yan Xi, Ge Wang
Keywords(s): Biomedical Engineering, computed tomography (CT), Diagnosis, Dual-energy X-ray CT, dual-layer x-ray detection, dual-source scanning, Imaging, kVp-switching, Measurement, Safety
Category(s): Biotechnology and the Life Sciences
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Training a CNN with pseudo ground truth for CT metal artifact reduction
RPI ID: 2018-021-201 / 2018-021-601Innovation Summary:This invention introduces a method for training convolutional neural networks (CNNs) to reduce artifacts in CT images using pseudo ground truth data. The system includes an estimated ground truth generator that produces reference images from artifact-laden scans, enabling the CNN to learn artifact...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Ge Wang, Lars Gjesteby, Hongming Shan
Keywords(s): Biomedical Engineering, machine-learning, medical imaging
Category(s): Computational Science and Engineering
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Simultaneous Emission-Transmission Tomography
RPI ID: 2017-028-401Innovation Summary:This invention presents a system for simultaneous emission and transmission imaging in PET/CT scanners. It features a rotating source and detector configuration that enables concurrent acquisition of PET and CT data. This design improves image registration, reduces scan time, and enhances workflow efficiency. The...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Ge Wang, Lars Gjesteby, Wenxiang Cong
Keywords(s): Biomedical Engineering, Diagnosis and treatment analysis of diseased tissue, medical imaging
Category(s): Biotechnology and the Life Sciences
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Intra-articular Potassium Injection for Osteoarthritis Treatment
RPI ID: 2017-027-201Innovation Summary:This invention introduces a method for treating joint pain and inflammation using intra-articular injections of potassium-based compositions. The formulation includes potassium salts and other agents that modulate nerve activity and reduce pain signaling. It provides localized, long-lasting relief without systemic...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Mariah Hahn, Joshua Erndt-Marino
Keywords(s): Biomedical Engineering, Biotechnology, Cellular Biology, Human healthcare, Small Molecule, Therapeutic/Drug, treatment method
Category(s): Biotechnology and the Life Sciences
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Apparatus and Method for Rapidly Changing X-ray Spectral Filtration
RPI ID: 2016-056-401, 2016-056-603, 2016-056-601, 2017-056-602Innovation Summary:This portfolio features a suite of advanced filtration technologies developed to enhance the performance of dual-energy X-ray computed tomography (DECT) systems. These innovations address key limitations in spectral separation, motion artifact reduction, and computational...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Ge Wang, Daniel Harrison
Keywords(s): Biomedical Engineering, Diagnostics, Human healthcare, Industrial Inspection, Industrial x-ray imaging, manufacturing, Measurement Systems, Medical device, Medical Imaging Technology, Security Inspection, Security x-ray Imaging, Transportation
Category(s): Biotechnology and the Life Sciences
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Energy-sensitive Multi-contrast Cost-effective CT (E=MC^2) System
RPI ID: 2016-047-401Innovation Summary:This invention presents a method for improving CT image reconstruction using a multi-contrast cost function. The system incorporates energy-sensitive data to enhance image quality and reduce artifacts. It is particularly effective in dual-energy and spectral CT imaging, where multiple contrast levels must be balanced....
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Wenxiang Cong, Ge Wang
Keywords(s): attenuation imaging, Biomedical Engineering, Diagnosis, grating imaging, Imaging, Measurement, phase-contrast imaging, Proteomics, x-ray dark-field imaging
Category(s): Biotechnology and the Life Sciences
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Simultaneous Interior MRI and X-ray Imaging System (MRX)
RPI ID: 2016-022-601 and 2016-022-401
Innovation Summary:
This invention presents a portable hybrid imaging system that combines magnetic resonance imaging (MRI) and X-ray modalities in a single device. The MRX system enables simultaneous acquisition of structural and soft tissue data, improving diagnostic precision. It uses compact electromagnets...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Lars Gjesteby, Ge Wang
Keywords(s): Biomedical Engineering, Diagnosis, Imaging, Interior Tomography
Category(s): Biotechnology and the Life Sciences
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Combination of an X-ray Tube and a G0 Grating with Electron Beam Scanning
RPI ID: 2016-006-401Innovation Summary:This invention presents a hybrid X-ray tube system that uses electron beam manipulation to replace the need for traditional source gratings. Instead of relying on mechanical source grating structures, the system modulates the X-ray output via controlled steering of the electron beam. The dynamic beam pattern generates...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Wenxiang Cong, Ge Wang
Keywords(s): Biomedical Engineering, Electrical Engineering, image reconstruction, Imaging, Molecular Modeling, x-ray dark-field imaging, X-ray grating imaging, x-ray phase imaging
Category(s): Biotechnology and the Life Sciences
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