RPI ID: 2016-017-401 and 2016-017-601
Innovation Summary:
This invention presents a drug delivery platform based on electrospun polymeric fibers that enable controlled, localized, and sustained release of therapeutic agents. The system uses biodegradable polymers to encapsulate drugs within nanofibers, allowing for precise tuning of release kinetics through fiber composition, structure, and drug-polymer interactions. The platform supports multi-layered fiber mats and spatially distinct drug loading, enabling complex release profiles for single or multiple drugs. This approach is particularly effective for applications requiring localized therapy with minimal systemic exposure.
Challenges / Opportunities:
Conventional drug delivery methods often result in burst release, poor targeting, and limited control over dosage timing. This technology addresses these issues by leveraging electrospinning to create customizable fiber architectures that mimic natural extracellular matrices. The ability to co-deliver multiple drugs with independent release profiles opens new opportunities in combination therapies, especially in oncology, wound healing, and regenerative medicine. The platform also aligns with the growing demand for implantable and patient-specific drug delivery systems.
Key Benefits / Advantages:
✔ Tunable drug release profiles (duration, rate, and sequence)
✔ Biocompatible and biodegradable materials
✔ Supports multi-drug and spatially controlled loading
✔ Reduces systemic side effects via localized delivery
✔ Scalable and reproducible electrospinning process
✔ Applicable to a wide range of therapeutic agents and indications
Applications:
• Post-operative pain management
• Chronic wound care and infection control
• Localized cancer therapy
• Tissue engineering and regenerative medicine
• Hormone or vaccine delivery systems
Keywords:
#electrospunfibers #controlleddrugrelease #biodegradablepolymers #localizedtherapy #nanofiberdrugdelivery #combinationtherapy
Intellectual Property:
• Issued Patent US11793877B2
• Issued Patent US12208139B2
