|
In Vitro Culture Model of Anisotropic to Isotropic Transition
RPI ID:
2015-010-401 / 2015-010-601
Innovation Summary:
A hybrid biomaterial platform integrates aligned electrospun fiber regions with adjacent isotropic film surfaces on a single culture substrate, creating a controlled anisotropic‑to‑isotropic boundary that models lesion‑edge transitions found in injured tissues such as spinal cord, tendon, and...
Published: 3/10/2026
|
Updated: 3/10/2026
|
Inventor(s): Gregory Desmond, Ryan Gilbert, Christopher Rivet, Jonathan Zuidema
Keywords(s): Architecture, Binaural Sound Localization, Biomedical Engineering, Echo Cancellation, Echo suppression, Electrical Engineering, Instrumentation, IT Hardware, Precedence Effect Model, Robotics, Sensors, Simulation and Modeling, Software
Category(s): Biotechnology and the Life Sciences
|
|
Synthesis and Processing of Poly(pro-drug) Materials for Extended Drug Release and Uses Thereof
RPI ID:
2019-013-401 / 2019-013-601
Innovation Summary:
A poly(pro‑drug) platform constructs biodegradable polymers in which the therapeutic molecule itself—such as estradiol, curcumin, or fingolimod—forms the repeating backbone, linked by cleavable ester, carbonate, or urethane groups and separated by hydrocarbyl or PEG‑based spacers....
Published: 3/10/2026
|
Updated: 3/10/2026
|
Inventor(s): Edmund Palermo, Anthony D'Amato, Ryan Gilbert, Samuel Ellman
Keywords(s): Biomaterial, Drug Delivery, hormone, pro-drug
Category(s): Biotechnology and the Life Sciences
|
|
Electrospun fibers with altered drug release profiles resulting from changes in polymer crystallinity
RPI ID: 2016-017-401 and 2016-017-601
Innovation Summary:
This invention presents a drug delivery platform based on electrospun polymeric fibers that enable controlled, localized, and sustained release of therapeutic agents. The system uses biodegradable polymers to encapsulate drugs within nanofibers, allowing for precise tuning of release kinetics...
Published: 7/21/2025
|
Updated: 7/7/2025
|
Inventor(s): Anthony D'Amato, Andrew Fiumara, Paul Troiano, Jesus Cardenas, Ryan Gilbert, Nicholas Schaub
Keywords(s): Biomedical Engineering, Delivery, Drug Delivery, Materials, Polymers
Category(s): Biotechnology and the Life Sciences
|
|
Implantable Multilayer 3D Scaffold Consisting of Highly Aligned Electrospun Fibers for Neuronal Regeneration Applications
RPI ID: 2016-014-401, 2016-014-601Innovation Summary:This invention introduces a 3D scaffold composed of curved, highly aligned electrospun fibers designed to promote neural regeneration. The scaffold mimics natural guidance structures found in peripheral nerve grafts, using polymer fibers arranged in S-shaped or C-shaped conduits. It may incorporate...
Published: 7/21/2025
|
Updated: 7/7/2025
|
Inventor(s): Ryan Gilbert, Jared Cregg, Bing Wang, Michael Mullins, Martin Oudega, Andres Hurtado
Keywords(s): biocompatible, Biomedical Engineering, Electrospinning, Electrospun Fibers, Implant, Material science, Nerve Regeneration, PLLA, Polymers, scaffold, Spinal Cord Injury
Category(s): Biotechnology and the Life Sciences
|
