RPI ID: 2016-014-401, 2016-014-601

Innovation Summary:
This invention introduces a 3D scaffold composed of curved, highly aligned electrospun fibers designed to promote neural regeneration. The scaffold mimics natural guidance structures found in peripheral nerve grafts, using polymer fibers arranged in S-shaped or C-shaped conduits. It may incorporate chemotactic agents, neurotrophins, and therapeutic molecules for improved regeneration outcomes. The design allows controlled release of biologics and compatibility with stem cells and support cells. The fabrication process includes electrospinning aligned fibers and molding them into 3D conduits without disrupting their structure. The scaffold can bridge large spinal cord lesions or peripheral nerve gaps. Its modularity supports integration with drug delivery systems and personalized therapy for central nervous system repair.

Challenges / Opportunities:
Spinal cord injuries remain among the most difficult medical conditions to treat due to lack of spontaneous regeneration. Conventional grafts face limitations in biocompatibility, sourcing, and efficacy. This invention solves these problems by combining biomimicry, scaffold architecture, and therapeutic delivery. It opens the door to customized nerve repair solutions that support axonal growth over longer distances. There is strong clinical demand for scaffold-based interventions that go beyond physical bridging to biologically active repair.

Key Benefits / Advantages:
✔ Biomimetic conduit design
✔ Supports axonal regeneration and cell growth
✔ Compatible with drug and cell therapies

Applications:
• Spinal cord repair
• Peripheral nerve regeneration
• Stem cell therapy delivery

Keywords:
#neuralregeneration #scaffold #spinalcordinjury #biomimeticdesign

Intellectual Property:
US Issued Patent(s) 10,413,391 B2, US 11,980,534 B2