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Hollow-lid tubes for diverse applications
RPI ID: 2023-040-301
Innovation Summary:
This invention introduces a novel class of hollow-lid tubes designed for biological, chemical, and diagnostic applications. These microfabricated containers feature a sealed, hollow interior with a removable or dissolvable lid, enabling precise control over the encapsulation and timed release of contents. The...
Published: 7/21/2025
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Updated: 7/8/2025
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Inventor(s): Deepak Vashishth, Grazyna Sroga
Keywords(s): biochip development, high-throughput dialysis, Hollow-lid tubes, hollow-wells of microtiter plates, membrane development, microscale implant testing
Category(s): Biotechnology and the Life Sciences
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Electrospun fibers with altered drug release profiles resulting from changes in polymer crystallinity
RPI ID: 2016-017-401 and 2016-017-601
Innovation Summary:
This invention presents a drug delivery platform based on electrospun polymeric fibers that enable controlled, localized, and sustained release of therapeutic agents. The system uses biodegradable polymers to encapsulate drugs within nanofibers, allowing for precise tuning of release kinetics...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Anthony D'Amato, Andrew Fiumara, Paul Troiano, Jesus Cardenas, Ryan Gilbert, Nicholas Schaub
Keywords(s): Biomedical Engineering, Delivery, Drug Delivery, Materials, Polymers
Category(s): Biotechnology and the Life Sciences
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Implantable Multilayer 3D Scaffold Consisting of Highly Aligned Electrospun Fibers for Neuronal Regeneration Applications
RPI ID: 2016-014-401, 2016-014-601Innovation Summary:This invention introduces a 3D scaffold composed of curved, highly aligned electrospun fibers designed to promote neural regeneration. The scaffold mimics natural guidance structures found in peripheral nerve grafts, using polymer fibers arranged in S-shaped or C-shaped conduits. It may incorporate...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Ryan Gilbert, Jared Cregg, Bing Wang, Michael Mullins, Martin Oudega, Andres Hurtado
Keywords(s): biocompatible, Biomedical Engineering, Electrospinning, Electrospun Fibers, Implant, Material science, Nerve Regeneration, PLLA, Polymers, scaffold, Spinal Cord Injury
Category(s): Biotechnology and the Life Sciences
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Detection of Cerebrospinal Fluid Leakage by Specific Measurement of Transferrin Glycoforms
RPI ID: 2015-062-402 Innovation Summary:This invention offers a rapid, selective method for detecting cerebrospinal fluid (CSF) leaks using a transferrin biomarker. A selective oxidation and binding step removes serum sialo-transferrin from a biological sample. The remaining asialo-transferrin, specific to CSF, is then measured. This biomolecular method...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Jonathan Dordick, Seok-Joon Kwon, Robert Linhardt, William Sonstein, Fuming Zhang
Keywords(s): Antibody, Assay, Enzyme, Immunoassay
Category(s): Biotechnology and the Life Sciences
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Translation Based Low-end Computed Tomography
RPI ID: 2014-031-201Innovation Summary:This invention introduces a linear scanning architecture for computed tomography (CT) that eliminates the need for rotational gantries. The system uses linearly translating X-ray sources and detectors moving in opposite or near-opposite directions. This arrangement enables tomographic imaging in environments where...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Wenxiang Cong, Fenglin Liu, Ge Wang, Hengyong Yu
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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Kalman filter based hypoglycemia prevention algorithm
RPI ID: 2013-062-201Innovation Summary:This invention involves a predictive algorithm that uses Kalman filtering to analyze glucose readings and forecast hypoglycemic events. The system collects real-time glucose data and estimates current levels and rates of change. By applying predictive models, it calculates future glucose trajectories. If a dangerous...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Wayne Bequette, Bruce Buckingham, Fraser Cameron, Peter Chase, Francis Doyle, Darrell Wilson
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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Nonlinear resistivity polymer composites filled with graphene oxide
RPI ID: 2012-014-401Innovation Summary:This invention introduces a graphene oxide-polymer composite material that exhibits nonlinear electrical resistivity, enabling its use in advanced sensing, switching, and protection applications. The material is formed by dispersing graphene oxide (GO) into a polymer matrix, resulting in a composite whose electrical...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Henrik Hillborg, Linda Schadler Feist, Zepu Wang, Su Zhao
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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Nanoparticles with Multiple Attached Polymer Assemblies and Use Thereof in Polymer Composites
RPI ID: 2012-010-602Innovation Summary:This invention describes a class of nanoparticles functionalized with multiple polymeric chains, enabling precise control over particle behavior in biological and chemical environments. The polymeric chains can be engineered for solubility, targeting, or responsiveness to environmental stimuli. This multifunctional...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Brian Benicewicz, Douglas Dukes, Atri Rungta, Linda Schadler Feist, Anand Viswanath
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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LT-TCP: End-to-End Framework to Improve TCP performance over Networks with Lossy Channels
RPI ID: 2005-012-202Innovation Summary:This invention introduces a modified version of the Transmission Control Protocol (TCP) designed to tolerate packet loss in high-bandwidth, high-latency networks. It adjusts congestion control mechanisms to maintain throughput despite losses, ensuring reliable data delivery without sacrificing speed. The protocol...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Shivkumar Kalyanaraman, K. K. Ramakrishnan, Vijaynarayanan Subramanian, Omesh Tickoo
Keywords(s): Electrical, Electronics
Category(s): Biotechnology and the Life Sciences
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Rapid Filtration Methods for Dual-energy X-ray CT
RPI ID: 2016-056-401, 2016-056-601, 2016-056-602, 2016-056-603Innovation Summary:This portfolio features a suite of advanced filtration technologies developed to enhance the performance of dual-energy X-ray computed tomography (DECT) systems. These innovations address key limitations in spectral separation, motion artifact reduction, and computational...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Wenxiang Cong, Yan Xi, Ge Wang
Keywords(s): Biomedical Engineering, computed tomography (CT), Diagnosis, Dual-energy X-ray CT, dual-layer x-ray detection, dual-source scanning, Imaging, kVp-switching, Measurement, Safety
Category(s): Biotechnology and the Life Sciences
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