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UNAFold version 4.0
RPI ID:
2017-042
Innovation Summary:
UNAFold® is a comprehensive software suite designed to simulate and predict nucleic acid folding, hybridization, and melting behavior using experimentally derived free energy parameters. It models secondary structures of single-stranded DNA or RNA, either individually or in pairs, under customizable temperature...
Published: 12/22/2025
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Updated: 12/22/2025
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Inventor(s): Nicholas Markham, Michael Zuker
Keywords(s): Bioinformatics, Biotechnology, Design, Diagnostics, discovery tool, DNA, healthcare, Human healthcare, modeling and simulation, molecular beacon, Molecular Biology, Molecular diagnostics, Nucleic acids, PCR primer, pharmaceutical, RNA, Software
Category(s): Biotechnology and the Life Sciences
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Novel use of Green Fluorescence Protein (GFP) and red fluorescence protein (RFP) and their derivatives to bind amyloid fibrils formed by enzymes, proteins, polypeptides, peptides, and hormones, both naturally occurring and lab-modified.
RPI ID: 2017-045-401Innovation Summary:Developed by RPI creators, this invention presents a novel system for detecting amyloid fibrils using engineered fluorescent proteins. The method enables sensitive and specific binding to amyloid aggregates, which are hallmarks of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. By leveraging the...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Changmingzi Xu-Fuery, Josephine LoRicco, Nathan James, Anthony Bishop, GEORGE MAKHATADZE
Keywords(s): Assay, biologic, biomarker, Biotechnology, Cellular Biology, Diagnostic system, Diagnostics, Drug Delivery, Drug Discovery, Human healthcare, Molecular Biology, pharmaceutical, protein/peptide, Proteins, research reagents/tools
Category(s): Biotechnology and the Life Sciences
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Apparatus and Method for Rapidly Changing X-ray Spectral Filtration
RPI ID: 2016-056-401, 2016-056-603, 2016-056-601, 2017-056-602Innovation Summary:This portfolio features a suite of advanced filtration technologies developed to enhance the performance of dual-energy X-ray computed tomography (DECT) systems. These innovations address key limitations in spectral separation, motion artifact reduction, and computational...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Ge Wang, Daniel Harrison
Keywords(s): Biomedical Engineering, Diagnostics, Human healthcare, Industrial Inspection, Industrial x-ray imaging, manufacturing, Measurement Systems, Medical device, Medical Imaging Technology, Security Inspection, Security x-ray Imaging, Transportation
Category(s): Biotechnology and the Life Sciences
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High Frequency Push-Push Oscillator
RPI ID: 2016-076-401Innovation Summary:This invention introduces a high-frequency push-push oscillator that utilizes a resonant circuit and Gm-core to generate a differential signal at twice the resonant frequency. The design incorporates a tank circuit and feedback mechanism to stabilize the output and reduce phase noise. Optimized for compact, high-performance...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Mona Hella, BASSEM FAHS
Keywords(s): Biological\Chem Separation\Purification Tech, Biomaterials, Biotechnology, camera/lens, Cellular Biology, Chip manufacturing, coatings/adhesives/composites, Devices/instruments, Diagnostic system, Diagnostics, Electrical Engineering, Engineering, Human computer interaction, Human healthcare, identification, Measurement Systems, Medical device, Medical Imaging Technology, Microelectronics, microscopy, modeling and simulation, Molecular Biology, Nanotechnology, neurons, Optical Systems, Optical waveguides, pharmaceutical, Photonics, photonics/microelectronics, research reagents/tools, scanning, security, Semiconductors, Sensors, terahertz
Category(s): Nanotechnology and Advanced Materials
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