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Detection of Cerebrospinal Fluid Leakage by Specific Measurement of Transferrin Glycoforms
RPI ID: 2015-062-402 Innovation Summary:This invention offers a rapid, selective method for detecting cerebrospinal fluid (CSF) leaks using a transferrin biomarker. A selective oxidation and binding step removes serum sialo-transferrin from a biological sample. The remaining asialo-transferrin, specific to CSF, is then measured. This biomolecular method...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Jonathan Dordick, Seok-Joon Kwon, Robert Linhardt, William Sonstein, Fuming Zhang
Keywords(s): Antibody, Assay, Enzyme, Immunoassay
Category(s): Biotechnology and the Life Sciences
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An assay to evaluate the filtration of suspended particles in existing and hypothetical micro-porous membranes
RPI ID: 2019-059-401Innovation Summary:This invention introduces a novel assay designed to evaluate the filtration efficiency of microporous membranes in removing suspended particles. The method leverages a controlled particle suspension and quantifies membrane performance through precise measurement of particle retention and flow characteristics. It...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Georges Belfort, Joel Plawsky, Corey Woodcock, Mirco Sorci, Dustin Andersen
Keywords(s): Assay, computational fluid mechanics, intermolecular forces, pore imaging, relative species transport rates, Selectivity
Category(s): Biotechnology and the Life Sciences
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Novel use of Green Fluorescence Protein (GFP) and red fluorescence protein (RFP) and their derivatives to bind amyloid fibrils formed by enzymes, proteins, polypeptides, peptides, and hormones, both naturally occurring and lab-modified.
RPI ID: 2017-045-401Innovation Summary:Developed by RPI creators, this invention presents a novel system for detecting amyloid fibrils using engineered fluorescent proteins. The method enables sensitive and specific binding to amyloid aggregates, which are hallmarks of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. By leveraging the...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Changmingzi Xu-Fuery, Josephine LoRicco, Nathan James, Anthony Bishop, GEORGE MAKHATADZE
Keywords(s): Assay, biologic, biomarker, Biotechnology, Cellular Biology, Diagnostic system, Diagnostics, Drug Delivery, Drug Discovery, Human healthcare, Molecular Biology, pharmaceutical, protein/peptide, Proteins, research reagents/tools
Category(s): Biotechnology and the Life Sciences
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Cell Chirality Based Three Dimensional Microassay for Disease Detection and Drug Screening
RPI ID: 2015-045-201Innovation Summary:This invention describes a 3D method for measuring cellular chirality, which is critical for early detection of diseases like cancer and developmental disorders. Cells are cultured in a multi-layered 3D substrate that mimics tissue environments more accurately than traditional 2D cultures. The system determines...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Amanda Chin, Qun (Leo) Wan
Keywords(s): Assay, Biomaterials\Tissue Engineering, Biomedical Engineering, Chirality, HTS, Imaging, Measurement, Morphogenesis, Stopper
Category(s): Biotechnology and the Life Sciences
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