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Enhanced Stability of Proteins Immobilized on Carbon Nanotubes
RPI ID:
2005-030-201
Innovation Summary:
This invention leverages the curvature of nanoparticles, such as carbon nanotubes, to enhance the stability and activity of proteins immobilized on their surfaces. Proteins bound to nanoscale curved surfaces retain biological activity even under harsh conditions, such as high temperature, organic...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Prashanth Asuri, Jonathan Dordick, Ravindra Kane, Sandeep Karajanagi, Alexey Vertegel, Richard Siegel
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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Heparin and Heparin Analogs with Exceptional Binding Affinity to SARS-CoV-2 Spike Protein as Potential Therapeutics
RPI ID: 2020-082-401 / 2020-082-601 / 2020-082-602
Innovation Summary:
Compositions containing sulfated polysaccharides such as pentosan polysulfate and mucopolysaccharide polysulfate are designed to inhibit SARS-CoV-2 by blocking viral entry and replication. These formulations are intended for mucosal delivery via nasal spray or aerosol, enabling...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): So Young Kim, Weihua Jin, Jonathan Dordick, Fuming Zhang, Seok-Joon Kwon, Paul Kwon, Keith Fraser, Robert Linhardt
Keywords(s): Heparin, Non-Anticoagulant Heparin, SARS-CoV-2 Spike Protein, TriS HS
Category(s): Biotechnology and the Life Sciences
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ImmunoMag-CRISPR lateral flow assay
RPI ID:
2024-015-301
Innovation Summary:
This technology introduces a point-of-care diagnostic system for urinary biomarkers using ultrasensitive ImmunoMag-CRISPR lateral flow assays. It combines magnetic bead-based sample preparation with CRISPR-based detection for enhanced sensitivity and specificity. The system is portable and designed for rapid,...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Inseon Lee, Peter Heeger, Jonathan Dordick, Seok-Joon Kwon
Keywords(s): Cas12a, CRISPR, Immunoassay, Kidney transplant rejection, lateral flow assay, Urinary biomarkers
Category(s): Biotechnology and the Life Sciences
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MPS and PPS and other sulfated GAG analogs to treat/prevent Monkeypox
RPI ID:
2023-007-601
Innovation Summary:
This technology describes therapeutic systems and methods using sulfated glycosaminoglycans (GAGs) and GAG analogs to treat or prevent monkeypox virus (Mpox) infections. The compounds interfere with viral attachment and entry mechanisms, reducing infectivity. The approach is designed for topical or systemic...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Robert Linhardt, Jonathan Dordick, Deling Shi, Fuming Zhang
Keywords(s): A29, Chondroitin sulfate, Dermatan sulfate, Heparin, Monkeypox virus
Category(s): Biotechnology and the Life Sciences
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Detection of Cerebrospinal Fluid Leakage by Specific Measurement of Transferrin Glycoforms
RPI ID: 2015-062-402 Innovation Summary:This invention offers a rapid, selective method for detecting cerebrospinal fluid (CSF) leaks using a transferrin biomarker. A selective oxidation and binding step removes serum sialo-transferrin from a biological sample. The remaining asialo-transferrin, specific to CSF, is then measured. This biomolecular method...
Published: 8/26/2025
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Updated: 7/7/2025
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Inventor(s): Jonathan Dordick, Seok-Joon Kwon, Robert Linhardt, William Sonstein, Fuming Zhang
Keywords(s): Antibody, Assay, Enzyme, Immunoassay
Category(s): Biotechnology and the Life Sciences
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Multiplex Detection of Bacterial Pathogens via Enzyme-Linked Cell Wall Binding Domain (CBD)-Sorbent Assay
RPI ID: 2017-059-402Innovation Summary:This invention introduces a novel biosensing platform for the multiplex detection of bacterial pathogens using engineered cell wall binding domain (CBD) complexes. These complexes selectively bind to bacterial cell walls and are conjugated with distinct reporter molecules, enabling simultaneous detection of multiple...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Seok-Joon Kwon, Jonathan Dordick, Domyoung Kim, Jungbae Kim, Inseon Lee
Keywords(s): Enzyme-Linked Cell Wall Binding Domain (CBD)-Sorbent Assay (, Multiplex Detection of Bacterial Pathogens
Category(s): Biotechnology and the Life Sciences
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Internalization of Proteins into Hollowed Gold Nanostructures
RPI ID: 2014-017-201 Innovation Summary:This invention enables the controlled delivery of proteins and biomolecules using hollow gold nanostructures. These nanocages are synthesized through a galvanic replacement process and functionalized with charged ligands. Payloads are adsorbed onto internal surfaces via electrostatic interactions. The method allows...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Jonathan Dordick, Jennifer Gagner, Xi Qian, Richard Siegel
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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