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Detection of Cerebrospinal Fluid Leakage by Specific Measurement of Transferrin Glycoforms
RPI ID: 2015-062-402 Innovation Summary:This invention offers a rapid, selective method for detecting cerebrospinal fluid (CSF) leaks using a transferrin biomarker. A selective oxidation and binding step removes serum sialo-transferrin from a biological sample. The remaining asialo-transferrin, specific to CSF, is then measured. This biomolecular method...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Jonathan Dordick, Seok-Joon Kwon, Robert Linhardt, William Sonstein, Fuming Zhang
Keywords(s): Antibody, Assay, Enzyme, Immunoassay
Category(s): Biotechnology and the Life Sciences
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Multiplex Detection of Bacterial Pathogens via Enzyme-Linked Cell Wall Binding Domain (CBD)-Sorbent Assay
RPI ID: 2017-059-402Innovation Summary:This invention introduces a novel biosensing platform for the multiplex detection of bacterial pathogens using engineered cell wall binding domain (CBD) complexes. These complexes selectively bind to bacterial cell walls and are conjugated with distinct reporter molecules, enabling simultaneous detection of multiple...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Seok-Joon Kwon, Jonathan Dordick, Domyoung Kim, Jungbae Kim, Inseon Lee
Keywords(s): Enzyme-Linked Cell Wall Binding Domain (CBD)-Sorbent Assay (, Multiplex Detection of Bacterial Pathogens
Category(s): Biotechnology and the Life Sciences
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Internalization of Proteins into Hollowed Gold Nanostructures
RPI ID: 2014-017-201 Innovation Summary:This invention enables the controlled delivery of proteins and biomolecules using hollow gold nanostructures. These nanocages are synthesized through a galvanic replacement process and functionalized with charged ligands. Payloads are adsorbed onto internal surfaces via electrostatic interactions. The method allows...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Jonathan Dordick, Jennifer Gagner, Xi Qian, Richard Siegel
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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