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Confined oil in beaded polymeric fibers with advanced thermoregulating properties
RPI ID:
2019-033-201, 2019-033-601
Innovation Summary:
A coaxial wet-wet electrospinning process enables the creation of core-shell microfibers, where the core contains a phase-change material (PCM) like coconut oil and the shell is composed of cellulose. The fibers are extruded into an ethanol-water coagulation bath, forming a beaded morphology with...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Ranodhi Udangawa, Charles Willard, Chiara Mancinelli, Caitlyn Chapman, Robert Linhardt, Trevor Simmons
Keywords(s): cellulose, Coconut oil, Core–shell microfiber composites, Electrospinning, Phase changing materials
Category(s): Energy, Environment and Smart Systems
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Novel nanocomposite fibers with a dramatic reduction in human plasma coagulation time
RPI ID:
2019-034-401
Innovation Summary:
This invention describes a method for producing cellulose-nanoclay hemostatic nanocomposite fibers. The process involves dissolving cellulose in a room-temperature ionic liquid and integrating nanoclay particles to form a homogenous solution. The resulting fibers exhibit dramatically reduced human plasma coagulation...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Ranodhi Udangawa, Chiara Mancinelli, Caitlyn Chapman, Charles Willard, Trevor Simmons, Robert Linhardt
Keywords(s): cellulose, Electrospinning, Halloysite clay, Hemostatic, Kaolin clay
Category(s): Nanotechnology and Advanced Materials
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Nasal spray using PPS and MPS for COVID-19 prevention and treatment
RPI ID: 2021-049-201
Innovation Summary:
A nasal spray formulation combines pentosan polysulfate and mucopolysaccharide polysulfate to prevent and treat COVID-19. The compounds act as viral entry inhibitors by blocking spike protein binding to host cells. The spray is designed for prophylactic and therapeutic use, with potential for broad-spectrum...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Fuming Zhang, Jawed Fareed, Walter Jeske, Robert Linhardt
Keywords(s): antiviral drug, COVID19, Heparin, mucopolysachharide polysulfate, Nasal spray, Pentosan polysulfate, prevention
Category(s): Biotechnology and the Life Sciences
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Heparin and Heparin Analogs with Exceptional Binding Affinity to SARS-CoV-2 Spike Protein as Potential Therapeutics
RPI ID: 2020-082-401 / 2020-082-601 / 2020-082-602
Innovation Summary:
Compositions containing sulfated polysaccharides such as pentosan polysulfate and mucopolysaccharide polysulfate are designed to inhibit SARS-CoV-2 by blocking viral entry and replication. These formulations are intended for mucosal delivery via nasal spray or aerosol, enabling...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): So Young Kim, Weihua Jin, Jonathan Dordick, Fuming Zhang, Seok-Joon Kwon, Paul Kwon, Keith Fraser, Robert Linhardt
Keywords(s): Heparin, Non-Anticoagulant Heparin, SARS-CoV-2 Spike Protein, TriS HS
Category(s): Biotechnology and the Life Sciences
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Microbial Synthesis of Sulfated Glycosaminoglycans
RPI ID: 2020-014-401
Innovation Summary:
Recombinant microorganisms are engineered to biosynthesize sulfated glycosaminoglycans (GAGs) directly in vivo, bypassing the need for animal-derived sources. The system incorporates genetic pathways for polymerization and sulfation, enabling controlled production of biologically active GAGs. This approach supports...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Abinaya Badri, Mattheos Koffas, Robert Linhardt, Asher Williams
Keywords(s): Animal-free Glycosaminoglycans, Metabolic engineering of E. coli, One pot microbial production of sulfated biologics
Category(s): Biotechnology and the Life Sciences
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MPS and PPS and other sulfated GAG analogs to treat/prevent Monkeypox
RPI ID:
2023-007-601
Innovation Summary:
This technology describes therapeutic systems and methods using sulfated glycosaminoglycans (GAGs) and GAG analogs to treat or prevent monkeypox virus (Mpox) infections. The compounds interfere with viral attachment and entry mechanisms, reducing infectivity. The approach is designed for topical or systemic...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Robert Linhardt, Jonathan Dordick, Deling Shi, Fuming Zhang
Keywords(s): A29, Chondroitin sulfate, Dermatan sulfate, Heparin, Monkeypox virus
Category(s): Biotechnology and the Life Sciences
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Detection of Cerebrospinal Fluid Leakage by Specific Measurement of Transferrin Glycoforms
RPI ID: 2015-062-402 Innovation Summary:This invention offers a rapid, selective method for detecting cerebrospinal fluid (CSF) leaks using a transferrin biomarker. A selective oxidation and binding step removes serum sialo-transferrin from a biological sample. The remaining asialo-transferrin, specific to CSF, is then measured. This biomolecular method...
Published: 8/26/2025
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Updated: 7/7/2025
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Inventor(s): Jonathan Dordick, Seok-Joon Kwon, Robert Linhardt, William Sonstein, Fuming Zhang
Keywords(s): Antibody, Assay, Enzyme, Immunoassay
Category(s): Biotechnology and the Life Sciences
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