RPI ID: 2015-062-402

Innovation Summary:
This invention offers a rapid, selective method for detecting cerebrospinal fluid (CSF) leaks using a transferrin biomarker. A selective oxidation and binding step removes serum sialo-transferrin from a biological sample. The remaining asialo-transferrin, specific to CSF, is then measured. This biomolecular method reduces the time required to confirm CSF leaks from several days to a matter of hours. The test is simple, accurate, and can be applied at the point of care or in a surgical suite. It enhances clinical decision-making during and after spinal surgery. It also improves diagnostic clarity in cases where symptoms are ambiguous.

Challenges / Opportunities:
Identifying CSF leakage after surgery can be difficult and time-consuming. Traditional tests like electrophoresis are delayed and not available in all clinical settings. This technology enables near-real-time confirmation of CSF presence, allowing faster response and better outcomes. There is a strong demand in neurosurgery and ENT for tools that improve intraoperative detection and postoperative care.

Key Benefits / Advantages:
✔ Rapid, selective CSF leak detection
✔ Biomarker-based test with low sample volume
✔ Supports real-time surgical decisions

Applications:
• Neurosurgery and spinal surgery
• Postoperative fluid diagnostics
• ENT and cranial procedures

Keywords:
#CSFleak #biomarkerdiagnostics #neurosurgery #transferrin

Intellectual Property:
US Issued Patent 11,067,581 B2