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Microbial Synthesis of Sulfated Glycosaminoglycans
RPI ID: 2020-014-401
Innovation Summary:
Recombinant microorganisms are engineered to biosynthesize sulfated glycosaminoglycans (GAGs) directly in vivo, bypassing the need for animal-derived sources. The system incorporates genetic pathways for polymerization and sulfation, enabling controlled production of biologically active GAGs. This approach supports...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Abinaya Badri, Mattheos Koffas, Robert Linhardt, Asher Williams
Keywords(s): Animal-free Glycosaminoglycans, Metabolic engineering of E. coli, One pot microbial production of sulfated biologics
Category(s): Biotechnology and the Life Sciences
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