RPI ID: 2014-017-201

Innovation Summary:
This invention enables the controlled delivery of proteins and biomolecules using hollow gold nanostructures. These nanocages are synthesized through a galvanic replacement process and functionalized with charged ligands. Payloads are adsorbed onto internal surfaces via electrostatic interactions. The method allows for long-term retention and sustained release of therapeutics or enzymes. By tuning the pore size relative to the size of the payload, controlled diffusion and bioavailability are achieved. This system is ideal for drug delivery and biosensing applications where precision and biocompatibility are crucial.

Challenges / Opportunities:
Conventional delivery systems for biologics suffer from poor targeting, fast clearance, or burst release. This invention improves therapeutic efficacy by using nano-engineered carriers with customized release profiles. It opens opportunities in targeted medicine, controlled release formulations, and smart diagnostics.

Key Benefits / Advantages:
✔ Precise control of payload release
✔ Biocompatible gold nanocages
✔ Suitable for a wide range of biomolecules

Applications:
• Targeted drug delivery
• Enzyme therapy
• Biomedical imaging

Keywords:
#goldnanocage #biodelivery #proteinloading #nanocarrier #controlledrelease

Intellectual Property:
US Issued Patent 9,562,225