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Peptide ligands for affinity capture of mRNA and methods of discovery thereof
RPI ID:
2022-060-301
Innovation Summary:
This technology describes peptide ligands engineered for the affinity capture of nucleic acids, including DNA and RNA, in solution. These ligands are designed to bind selectively to nucleic acid targets, enabling efficient isolation and purification. The method includes synthesis and screening of peptide sequences...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Pankaj Karande, Mengyang Hu, Georges Belfort
Keywords(s): mRNA, Peptides, Purification, Vaccine
Category(s): Biotechnology and the Life Sciences
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Ligand design method for affinity capture of mRNA in solution and on a surface and ligands discovered thereof
RPI ID:
2022-061-601
Innovation Summary:
This technology describes ligands and associated methods for affinity capture of mRNA molecules in solution. The ligands are designed to bind selectively to mRNA surfaces, enabling efficient isolation and purification. The system supports scalable mRNA processing for therapeutic and research applications. It...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Todd Przybycien, Mirco Sorci, Thomas Neuman, Riddhi Banik, Georges Belfort
Keywords(s): mRNA, Purification, Vaccine
Category(s): Biotechnology and the Life Sciences
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Directed evolution for Membranes Development in 3 Dimensions
RPI ID: 2021-036-201
Innovation Summary:
Directed evolution techniques are applied to develop three-dimensional membrane structures with enhanced permeability and selectivity. The system uses iterative mutation and selection cycles to optimize membrane protein configurations. It supports applications in filtration, sensing, and biointerfaces. The method...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Joel Plawsky, Mirco Sorci, Chenyu Guan, Georges Belfort
Keywords(s): bioprocessing, food processing, membrane microfiltration, Separations
Category(s): Biotechnology and the Life Sciences
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Tunable hydrophilic crosslinked polymer membranes for separation applications
RPI ID:
2023-044-601
Innovation Summary:
This technology provides hydrophilic crosslinked polymer membranes with tunable properties for separation applications. The membranes are engineered to adjust water uptake, permeability, and selectivity through controlled crosslinking. They are designed for use in aqueous environments and support high-efficiency...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Pranav Ramesh, Georges Belfort
Keywords(s): Nanofiltration, Separation, Surface polymerization
Category(s): Energy, Environment and Smart Systems
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Fused particle membranes for filtration: Material and methods
RPI ID:
2023-016-301
Innovation Summary:
This technology introduces filtration systems using fused particle membranes that offer enhanced mechanical strength and selective permeability. The membranes are formed by thermally bonding particles into a porous structure, allowing precise control over pore size and distribution. The system is suitable for...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Surya Karla, Joel Plawsky, Georges Belfort
Keywords(s): Desalination, fouling, Membranes, Polymeric membranes
Category(s): Biotechnology and the Life Sciences
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An assay to evaluate the filtration of suspended particles in existing and hypothetical micro-porous membranes
RPI ID: 2019-059-401Innovation Summary:This invention introduces a novel assay designed to evaluate the filtration efficiency of microporous membranes in removing suspended particles. The method leverages a controlled particle suspension and quantifies membrane performance through precise measurement of particle retention and flow characteristics. It...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Georges Belfort, Joel Plawsky, Corey Woodcock, Mirco Sorci, Dustin Andersen
Keywords(s): Assay, computational fluid mechanics, intermolecular forces, pore imaging, relative species transport rates, Selectivity
Category(s): Biotechnology and the Life Sciences
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Combined Plasma-ARGET ATRP Method and Materials For Modifying Poly(ether sulfone) Surface
RPI ID: 2017-007-401Innovation Summary:This invention presents a method for modifying polymeric surfaces using atmospheric pressure plasma followed by atom transfer radical polymerization (ATRP). The process activates the surface, attaches an initiator, and then grows polymer chains to tailor surface properties. It enables precise control over surface...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Georges Belfort, Istvan Kocsis, Mirco Sorci, Alexander Lee, John Keating
Keywords(s): Advanced Materials, ARGET ATRP, Biological\Chem Separation\Purification Tech, Biotechnology, Chemistry, coatings/adhesives/composites, Consumer product, Desalination, Design, Devices, Devices/instruments, Energy, Energy efficiency, Environment, Films, Human healthcare, Material science, membrane systems, Membrane Technology, Membranes, Nanotechnology, Nanotechnology (nanocomposites), Organics Recovery, pharmaceutical, plasma, plastics, Polymer Brush, polymer composite, polymer/epoxy resins, polymerization, Polymers, Proteins, research reagents/tools, Sensors, Surface modification, Technology
Category(s): Nanotechnology and Advanced Materials
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Hydrophobic Brush Membranes for Filtration Based on Solution-Diffusion Mechanism with Applications to Pervaporation (PV) & Reverse Osmosis (RO)
RPI ID: 2015-029-401, 2015-029-601, 2015-029-602, 2015-029-603Innovation Summary:This invention describes a synthetic membrane system designed to purify water and isolate volatile organic compounds. The membrane includes a hydrophobic polymer layer supported by a polymeric substrate, allowing for selective pervaporation or reverse osmosis. The technology...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Georges Belfort, Joseph Grimaldi, Joseph Imbrogno, James Kilduff
Keywords(s): Chemical Engineering, Energy, Energy Management, Material Sciences\Engineering, Materials, Monomers, Polymers, Purification, Small Molecule
Category(s): Biotechnology and the Life Sciences
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Anti-fouling Chiral Surfaces for Membrane Filtration
RPI ID: 2015-002-402, 2015-002-601, 2015-002-602 Innovation Summary:This innovation builds upon chiral membrane technology by providing multiple patented refinements in design and manufacturing methods. The surface-modified membranes reduce fouling by interfering with the adhesion of biomolecules. Utilizing optically active monomers, these surfaces...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Georges Belfort, Joseph Imbrogno
Keywords(s): Analgesic, Analytical Chemistry, Cell Therapy, Drug Delivery, Gene Therapy, Magnetogenetics, Nanomagnets, Nanostructures, Nanotechnology & Science, Remote Activation
Category(s): Biotechnology and the Life Sciences
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A method for designing active antimicrobial peptides (AMPs) specific for a given bacterial target and three highly active synthetic AMPs designed using this method against Mycobacterium tuberculosis
RPI ID: 2014-043-601Innovation Summary:This invention introduces a set of novel anti-microbial peptides effective against M. tuberculosis and streptococcus species. The peptides were developed using a computational design strategy to enhance biological activity and specificity while minimizing toxicity to human cells. The design methodology allows researchers...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Georges Belfort, Pankaj Karande, Zachary Kloos, Jun Kwak, Kathleen McDonough, Brian Murray, Carl Pearson
Keywords(s):
Category(s): Biotechnology and the Life Sciences
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