Ligand design method for affinity capture of mRNA in solution and on a surface and ligands discovered thereof
RPI ID:
2022-061-601
Innovation Summary:
This technology describes ligands and associated methods for affinity capture of mRNA molecules in solution. The ligands are designed to bind selectively to mRNA surfaces, enabling efficient isolation and purification. The system supports scalable mRNA processing for therapeutic and research applications. It is optimized for use in liquid-phase environments, enhancing compatibility with automated workflows.
Challenges / Opportunities:
Current mRNA purification methods can be inefficient or require complex instrumentation. This invention addresses the need for high-affinity, solution-phase capture techniques. It opens opportunities for improving mRNA-based drug manufacturing and diagnostics. The method also supports integration into high-throughput screening and bioprocessing platforms.
Key Benefits / Advantages:
✔ High-affinity binding to mRNA surfaces
✔ Enables efficient capture in solution
✔ Scalable for therapeutic and research use
✔ Compatible with automated workflows
Applications:
• mRNA purification for therapeutics and diagnostics
Keywords:
mRNA capture, affinity ligands, bioprocessing, RNA purification, molecular diagnostics
Intellectual Property:
US20250059528A1 (Application 18/936186), Published November 4, 2024
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