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Electrospun fibers with altered drug release profiles resulting from changes in polymer crystallinity
RPI ID: 2016-017-401 and 2016-017-601
Innovation Summary:
This invention presents a drug delivery platform based on electrospun polymeric fibers that enable controlled, localized, and sustained release of therapeutic agents. The system uses biodegradable polymers to encapsulate drugs within nanofibers, allowing for precise tuning of release kinetics...
Published: 7/21/2025
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Updated: 7/7/2025
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Inventor(s): Anthony D'Amato, Andrew Fiumara, Paul Troiano, Jesus Cardenas, Ryan Gilbert, Nicholas Schaub
Keywords(s): Biomedical Engineering, Delivery, Drug Delivery, Materials, Polymers
Category(s): Biotechnology and the Life Sciences
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Novel use of Green Fluorescence Protein (GFP) and red fluorescence protein (RFP) and their derivatives to bind amyloid fibrils formed by enzymes, proteins, polypeptides, peptides, and hormones, both naturally occurring and lab-modified.
RPI ID: 2017-045-401Innovation Summary:Developed by RPI creators, this invention presents a novel system for detecting amyloid fibrils using engineered fluorescent proteins. The method enables sensitive and specific binding to amyloid aggregates, which are hallmarks of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. By leveraging the...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Changmingzi Xu-Fuery, Josephine LoRicco, Nathan James, Anthony Bishop, GEORGE MAKHATADZE
Keywords(s): Assay, biologic, biomarker, Biotechnology, Cellular Biology, Diagnostic system, Diagnostics, Drug Delivery, Drug Discovery, Human healthcare, Molecular Biology, pharmaceutical, protein/peptide, Proteins, research reagents/tools
Category(s): Biotechnology and the Life Sciences
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Anti-fouling Chiral Surfaces for Membrane Filtration
RPI ID: 2015-002-402, 2015-002-601, 2015-002-602 Innovation Summary:This innovation builds upon chiral membrane technology by providing multiple patented refinements in design and manufacturing methods. The surface-modified membranes reduce fouling by interfering with the adhesion of biomolecules. Utilizing optically active monomers, these surfaces...
Published: 7/21/2025
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Updated: 7/3/2025
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Inventor(s): Georges Belfort, Joseph Imbrogno
Keywords(s): Analgesic, Analytical Chemistry, Cell Therapy, Drug Delivery, Gene Therapy, Magnetogenetics, Nanomagnets, Nanostructures, Nanotechnology & Science, Remote Activation
Category(s): Biotechnology and the Life Sciences
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