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Synthesis and Processing of Poly(pro-drug) Materials for Extended Drug Release and Uses Thereof
RPI ID:
2019-013-401 / 2019-013-601
Innovation Summary:
A poly(pro‑drug) platform constructs biodegradable polymers in which the therapeutic molecule itself—such as estradiol, curcumin, or fingolimod—forms the repeating backbone, linked by cleavable ester, carbonate, or urethane groups and separated by hydrocarbyl or PEG‑based spacers....
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Edmund Palermo, Anthony D'Amato, Ryan Gilbert, Samuel Ellman
Keywords(s): Biomaterial, Drug Delivery, hormone, pro-drug
Category(s): Biotechnology and the Life Sciences
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A Method for Generating Functional Surface Coatings and Modifications via Self-Assembly of Silk Fibroin and Silk Fibroin-Like Macromolecules
RPI ID:
2019-087-401
Innovation Summary:
A non-covalent, bottom-up coating method enables the formation of silk fibroin-based layers on chemically inert and geometrically complex surfaces. The process uses kosmotropic agents to facilitate smooth, homogeneous coatings that are tunable in thickness and free of inhomogeneities. These coatings can incorporate...
Published: 4/9/2026
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Updated: 3/10/2026
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Inventor(s): Runye Zha, Tanner Fink, Caleb Wigham
Keywords(s): antifouling coatings, bioinert, Biomaterial, biomedical coatings, Implant, implant surface, protein structure, Self Assembly, silk, spidroin, Surface modification, surface treatment, thin film coatings, universal coating
Category(s): Biotechnology and the Life Sciences
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Recombinant Production of Silk Proteins via Bacillus Megaterium Secretion (Updated)
RPI ID:
2023-070-301
Innovation Summary:
This technology enables the recombinant production of silk proteins using Bacillus megaterium as a secretion host. The system leverages the bacterium’s natural secretion pathways to produce and release silk proteins extracellularly, simplifying downstream purification. The method supports scalable production...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Mattheos Koffas, Runye Zha, Alexander Connor
Keywords(s): advanced polymers, Biodegradable materials, Biomaterial, Biomedical material, Biomimetic material, green polymer synthesis, Materials, silk, sustainable
Category(s): Biotechnology and the Life Sciences
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