RPI ID: 2004-013-601

Innovation Summary:
This invention introduces a novel method for identifying kinetically stable proteins, which are proteins that resist unfolding over time and under stress. The method involves exposing proteins to chemical denaturants and analyzing their resistance to unfolding using chromatographic techniques. Kinetically stable proteins are of particular interest in biotechnology and pharmaceutical development due to their enhanced durability and functional longevity. This approach enables researchers to screen for proteins with superior stability profiles, which are ideal for therapeutic, industrial, and diagnostic applications.

Challenges / Opportunities:
Traditional protein stability assessments often focus on thermodynamic stability, which does not always correlate with functional resilience in real-world conditions. This invention addresses that gap by focusing on kinetic stability—how long a protein remains folded and functional under stress. It opens opportunities in drug development, enzyme engineering, and protein-based diagnostics, where long-term stability is critical for performance and shelf life.

Key Benefits / Advantages:
✔ Enables identification of proteins with superior kinetic stability
✔ Non-destructive and scalable screening method
✔ Applicable to a wide range of protein types and sources
✔ Enhances development of robust biopharmaceuticals and enzymes

Applications:
• Therapeutic protein and antibody development
• Industrial enzyme design and optimization
• Protein-based biosensors and diagnostics
• Structural biology and protein engineering research

Keywords:
#proteinengineering #kineticstability #biopharmaceuticals #enzymestability #proteinscreening

Intellectual Property:
US Issued Patent 7,217,348