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Downregulation of Promoter Strength for Increased Production of Recombinant Biopolymers
RPI ID: 2021-070-401
Innovation Summary:
Recombinant E. coli strains and synthetic protein sequence designs are used to produce disordered polypeptides such as spidroins and elastin-like peptides (ELPs). The system leverages genome engineering to suppress basal expression and redirect cellular resources toward target biopolymer synthesis. This approach...
Published: 3/10/2026
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Updated: 3/10/2026
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Inventor(s): Mattheos Koffas, Derek Nelson, Runye Zha, Alexander Connor
Keywords(s): Biomanufacturing, Biomaterials, Recombinant Protein Engineering, Sustainable Materials
Category(s): Biotechnology and the Life Sciences
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