RPI ID: 2018-013-401

Innovation Summary:
This invention introduces a stationary in-vivo grating-enabled micro-CT system, known as SIGMA. The architecture eliminates the need for mechanical rotation by using a fixed array of X-ray sources and detectors arranged in a circular geometry. Grating-based interferometry is integrated into the system to enhance soft tissue contrast and phase sensitivity. This design enables high-resolution, low-dose imaging suitable for dynamic and longitudinal studies in small animals and potentially in clinical applications.

Challenges / Opportunities:
Conventional micro-CT systems rely on rotating gantries, which limit temporal resolution and introduce mechanical complexity. These systems are also less suited for in-vivo imaging of live subjects due to motion artifacts and radiation dose concerns. The SIGMA architecture addresses these limitations by offering a stationary, high-speed imaging platform with improved contrast and reduced motion sensitivity. It opens new opportunities in preclinical research, drug development, and advanced diagnostic imaging.

Key Benefits / Advantages:
✔ Stationary design eliminates mechanical motion artifacts
✔ Grating-based interferometry enhances soft tissue contrast
✔ High temporal and spatial resolution
✔ Reduced radiation dose for in-vivo imaging
✔ Ideal for dynamic and longitudinal studies

Applications:
• Preclinical imaging in small animal models
• Longitudinal disease progression studies
• Drug efficacy and toxicity monitoring
• Advanced diagnostic imaging research
• Low-dose imaging in sensitive populations

Keywords:
#microCT #stationaryCT #gratinginterferometry #invivoimaging #phasecontrast #preclinicalimaging

Intellectual Property:
US Issued Patent 11,382,574 B2