RPI ID: 2014-029-201
Innovation Summary:
This imaging method leverages stored luminescence from nanophosphors embedded in biological samples to produce high-resolution, three-dimensional images. Unlike traditional computed tomography that requires real-time excitation and signal capture, this system decouples excitation from readout. First, X-ray irradiation charges the luminescent nanoparticles in the sample. Later, near-infrared (NIR) light or other low-energy stimulation reactivates the particles to emit light, which is then captured for tomographic reconstruction. This separation allows more flexible imaging protocols and reduces the total radiation exposure. The system supports high spatial and temporal resolution, as well as selective signal targeting. Its ability to use stored light enhances contrast and depth penetration, making it valuable in preclinical research and biomedical diagnostics. The technology is compatible with optical multiplexing and can be extended to multi-spectral imaging for functional studies.
Challenges / Opportunities:
Conventional CT methods lack molecular sensitivity and often require high doses of ionizing radiation, limiting their use in longitudinal or pediatric studies. Furthermore, the need for simultaneous stimulation and detection constrains system design and flexibility. This invention solves both problems by introducing time-delayed readout and spatially precise activation of luminescent markers. It allows clinicians and researchers to perform more informative scans with reduced invasiveness. There is a growing market for molecular imaging techniques that can complement anatomical scans. Stored luminescence tomography meets this need by bridging the gap between high-resolution structural imaging and functional insight. Opportunities abound in drug tracking, disease monitoring, and personalized diagnostics.
Key Benefits / Advantages:
✔ Decoupled excitation and readout
✔ Reduced radiation exposure
✔ High contrast and resolution
Applications:
• Molecular imaging
• Preclinical diagnostics
• Nanomedicine tracking
Keywords:
#computedtomography #nanophosphors #infraredimaging #moleculardiagnostics
Intellectual Property:
US Issued Patent 10,285,659 B2
